From its conception, paediatric HIV research has been at the heart of PHRU’s mission. In the early days of the epidemic, against all odds, PHRU established prevention of mother-to-child transmission of HIV in Soweto. Today, building on nearly two decades of success in researching and implementing prevention of mother-to-child transmission (PMTCT) and paediatric treatment programmes, our team of researchers, doctors, nurses, counsellors, data capturers and the residents of Soweto embark on innovative research efforts to answer some of the final questions that remain around how to prevent and treat HIV among infants and children.

Clinical Trials and Research

PHRU works with a range of partners [internal link] to conduct world-class paediatric HIV research. Our research has shaped international guidelines and practice and has affected countless women and children throughout South Africa and the world. Learn more about our ongoing clinical trials and research studies.


Every day our staff sees patients at the Paediatric Wellness Clinic, a PEPFAR-funded state-of-the-art clinic situated at the Chris Hani Baragwanath Hospital where we offer care, treatment and support to over two thousand children and their families.

Learn more about our Paediatric Wellness Clinic.

Prevention of Mother-to-Child Transmission at PHRU

PHRU was instrumental in bringing PMTCT to South Africa—from conducting groundbreaking research that rewrote international PMTCT guidelines, expanding PMTCT services throughout Soweto, advocating for the South African government to provide those services and demonstrating a successful and adaptable model for PMTCT programming. In 2001, PHRU established PMTCT programmes at Chris Hani Baragwanath Hospital and at each of the thirteen antenatal clinics throughout Soweto. Today, PHRU’s various service programmes and clinics [internal link to ‘Our Services’] link to its PMTCT services—further expanding access to this important programme.

Learn more about how HIV-positive women can help protect their babies from HIV.