One of Africa's leading medical and social research centres into Aids and HIV
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2005 Publications

Article Index
2005 Publications
2005 Publications (Part II)
2005 Publications (Part III)
2005 Publications (Part IV)
2005 Publications (Part V)
2005 Publications (Part VI)
All Pages

2003-2005 (PDF format,132kb )


2005 – Papers and publications

PHRU Overview: 1996 to 2005

This report details the achievements of the Perinatal HIV Research Unit’s (PHRU) comprehensive HIV/AIDS research programme over the past 10 years. The report focuses on recent achievements but also provides a brief overview of the earlier days.
Download the report. [PDF, 1.45MB] Use Acrobat Reader version 6 or later.

Journal articles: 2005

Chersich M, Gray G: Progress and emerging challenges in preventing mother-to-child transmission. Curr Infect Dis Rep. 2005 Sep;7(5):393-400. Review.

Coovadia H, Fowler MG, Lockman S, McIntyre J. Roundtable. Revisiting the role of single-dose nevirapine for preventing perinatal HIV transmission. AIDS Clin Care. 2005 Jul;17(7):61-4.

Coplan PM, Gupta SB, Dubey SA, Pitisuttithum P, Nikas A, Mbewe B, Vardas E, Schechter M, Kallas EG, Freed DC, Fu TM, Mast CT, Puthavathana P, Kublin J, Brown Collins K, Chisi J, Pendame R, Thaler SJ, Gray G, McIntyre J, Straus WL, Condra JH, Mehrotra DV, Guess HA, Emini EA, Shiver JW. Cross-reactivity of anti-HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1-positive individuals from 4 continents. J Infect Dis. 2005 May 1;191(9):1427-1434.

Dabis F, Balestre E, Braitstein P, Miotti P, Brinkhof WG, Schneider M, Schechter M, Laurent C, Boulle A, Kabugo C, Capkun G, Seyler C, McIntyre J, Sprinz E, Bangsberg D, Van der Borght S, Egger M; The Antiviral Therpapy in Lower Income Countries (ART-LINC) Study Group. Cohort profile: Antiretroviral therapy in lower income countries (ART-LINC): international collaboration of treatment cohorts. Int J Epidemiol. 2005 Oct;34(5):979-86.

De Bruyn G. Diarrhoea in adults (acute). Clin Evid. 2005 Jun;(13):896-916. Review.

De Bruyn G, Hudgens MG, Sullivan PS, Duerr A. Participant retention in clinical trials of candidate HIV vaccines. J Acquir Immune Defic Syndr. 2005 Aug 1;39(4):499-501.

De Bruyn G, Vargas-Cortez M, Warren T, Tyring SK, Fife KH, Lalezari J, Brady RC, Shahmanesh M, Kinghorn G, Beutner KR, Patel R, Drehobl MA, Horner P, Kurtz TO, McDermott S, Wald A, Corey L. A Randomised controlled trial of a replication defective (gH deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects. Vaccine. 2005 Sep 21; In press, online publication Sep 2, 2005.

Gray GE, Urban M, Chersich MF, Bolton C, van Niekerk R, Violari A, Stevens W, McIntyre JA for the PEP Study Group. A randomised trial of two post-exposure prophylaxis regimens to reduce mother-to-child HIV-1 transmission in infants of untreated mothers. AIDS 2005 Aug 12, 19:1289-1297.

Gray CM, Williamson C, Bredell H, Puren A, Xia X, Filter R, Zijenah L, Cao H, Morris L, Vardas E, Colvin M, Gray G, McIntyre J, Musonda R, Allen S, Katzenstein D, Mbizo M, Kuwenda N, Taha T, Karim SA, Flores J, Sheppard HW. Viral Dynamics and CD4 T cell counts in subtype C human immunodeficiency virus type 1-infected individuals from southern Africa. AIDS Res Hum Retroviruses 2005, Apr 21 (4) 285-91.

Jaspan HB, Gray GE, Robinson AK, Coovadia HM, Bekker LG. Scientific justification for the participation of children and adolescents in HIV-1 vaccine trials in South Africa. S Afr Med J. 2005 Sep;95(9):685-7.

Johnson JA, Li JF, Morris L, Martinson N, Gray G, McIntyre J, Heneine W. Emergence of drug-resistant HIV-1 after intrapartum adminstration of single-dose nevirapine is substantially underestimated. J Infect Dis. 2005 Jul 1;192(1):16-23.

Leroy V, Sakarovitch C, Cortina-Borja M, McIntyre J, Coovadia H, Dabis F, Newell ML, Saba J, Gray G, Ndugwa Ch, Kilewo Ch, Massawe A, Kituuka P, Okong P, Grulich A, von Briesen H, Goudsmit J, Biberfeld G, Haverkamp G, Weverling GJ, Lange JM; Ghent Group on HIV in Women and Children. Is there a difference in the efficacy of peripartum antiretroviral regimens in reducing mother-to-child transmission of HIV in Africa? AIDS, 2005 Nov 4; 19(16):1865-75.

Madhi SA, Zar HJ, Saloojee H, Gray GE. Co-trimoxazole prophylaxis in African children with HIV-1. Lancet. 2005 Feb 26;365(9461):749-50. Letter.

McIntyre J. Maternal health and HIV. Reprod Health Matters. 2005 May;13(25):129-35.

McIntyre J. Preventing mother-to-child transmission of HIV: successes and challenges. BJOG. 2005 Sep;112(9):1196-203. Review.

McIntyre JA. Sex, pregnancy, hormones, and HIV. Lancet. 2005 Oct 1;366(9492):1141-2.

McIntyre J. Prevention of mother-to-child transmission of HIV: treatment options. Expert Rev Anti Infect Ther. 2005 Dec;3(6):971-80.

Naeem-Sheik A, Gray G. HIV Disclosure in Children. S Afr J HIV Medicine, Nov 2005: 46-48.

Rose P, Violari A, Bolton C, Gray GE. Feasibility and acceptability of postpartum voluntary counselling and testing (PPVCT) in a large tertiary hospital in the South African setting. S Afr J HIV Medicine, June 2005: (19):8-10. Review.

Swartz L, Bhana A, Gray G, Kafaar Z, et al (2005). Social and behavioural aspects of child and adolescent participation in HIV vaccine trials. J Int Assoc Physicians in AIDS Care, 4(4):89-92.

Vardas E, Butto S, Glashoff R, Malnati MS, Poli G, Clerici M. Preparing for phase II/III HIV vaccine trials in Africa. Microbes Infect. 2005 Nov;7(14):1436-44.


Group publications: 2005

The Breastfeeding and HIV International Transmission Study Group. Mortality among HIV-1 infected women according to children’s feeding modality: an individual patient data meta-analysis. J Acquir Immune Defic Syndr. 2005;39:430-438.

Submitted publications: 2005

Heyer AS, Ogunbanjo GA. Adherence to HIV Anti-retroviral Therapy Part I – Factors Related to Treatment Regimen. Submitted to SA Family Practice, received on 7 September 2005.

Book chapters: 2005

Mfecane S, Struthers H, Gray G and McIntyre J. How masculinity and lifestyle of drinking in shebeens interact to create risks for transmission of HIV/AIDS in a black township in South Africa. In Anita Hardin and Diana Ginson (eds). Rethinking Gender and Masculinities. Confronting issues of health. 2005 Nederlands: Spinhuis publishers.

Oral presentations: 2005

De Bruyn G, Diagnosis of childhood tuberculosis. 1st Priorities in AIDS Care and Treatment conference, 2005.

Dladla S, Robertson G. Couple HIV counselling and testing as entry to treatment and care. 1st Priorities in AIDS Care and Treatment conference, 2005.

Grey GE. The current debate: Routine HIV screening or VCT? (Plenary) 1st Conference on Priorities in AIDS Care and Treatment, Muldersdrift, Johannesburg, 19 – 22 April 2005

Gray G, van Niekerk R, Urban M, Violari A, McIntyre J, Martinson N, PEP Study Group. Death and hospital admissions in infants born to HIV-infected women. Abstract 803. 12th Conference on Retroviruses and Opportunistic Infections. 22-25 February 2005. Boston, MA.

Heyer A, Steyn J, Pronyk P, Gray G, McIntyre J, Struthers H, Martinson N. Prevalence and risk factors for pre-malignant cervical lesions in HIV infected women. Abstract MoPe11.2.33 3rd Conference on HIV Pathogenesis and Treatment. 24-27 July 2005, Rio de Janeiro.

Johnson J, Lil JF, Morris L, Martinson N, Gray G, J McIntyre J, Henein W. Resistance emerges in the majority of women provided intrapartum single-dose nevirapine. Abstract 100. 12th Conference on Retroviruses and Opportunistic Infections. 22-25 February 2005. Boston, MA.

Jooste I, Struthers H. Wanting more from the media: audiences in high HIV prevalence areas say news does not represent their reality. 3rd African Conference for the Research on the Social Aspects of the HIV / AIDS, “Bridging the gap between policy, research and interventions”, Dakar, Senegal October 10th -14th 2005

Martinson N. An integrated approach to primary HIV care. 1st Conference on Priorities in AIDS Care and Treatment, Muldersdrift, Johannesburg, 19 – 22 April 2005

Martinson N, Heyer A, Steyn J, Struthers H, McIntyre J, Gray G, Pronyk P. Does WHO clinical stage reliably predict who should receive ARV treatment? Abstract WeFO0304, 3rd Conference on HIV Pathogenesis and Treatment. 24-27 July 2005, Rio de Janeiro .

Martinson N, Lupondwana P, Morris L, Ntsala M, Puren A, Chezzi C, Dhlamini P, Cohen S, Gray G, Steyn J McIntyre J. Effectiveness of Single-dose Nevirapine in a Second Pregnancy. Abstract 103. 12th Conference on Retroviruses and Opportunistic Infections. 22-25 February 2005. Boston, MA.

McIntyre JA. Controversies in the use of nevirapine for the prevention of mother-to-child transmission of HIV. (Plenary) 12th Conference on Retroviruses and Opportunistic Infections, Boston, February 22 -2 5 2005

McIntyre JA. New developments in the prevention of mother-to-child transmission of HIV. (Plenary) 1st Conference on Priorities in AIDS Care and Treatment, Muldersdrift, Johannesburg, 19 – 22 April 2005

McIntyre JA. Addition of short course Combivir (CBV) to single dose Viramune (sdNVP) for prevention of mother to child transmission (pMTCT) of HIV-1 can significantly decrease the subsequent development of maternal NNRTI-resistant virus. 3rd IAS conference on HIV pathogenesis and Treatment. Rio de Janeiro, 24 – 27 July 2005

McIntyre JA. New directions in the science of AIDS prevention. (Plenary) University of the Witwatersrand Faculty of Health Sciences Research Day, 4 August 2005

McIntyre JA. The Impact of HIV on pregnant women in South Africa. (Opening Plenary) 32nd National Conference of the South African Society of Obstetricians and Gynaecologists, Drakensberg, 4 – 7 September 2005

McIntyre JA. Antiretroviral treatment in South Africa. New approaches to HIV management. Centes Garde Symposium, Beijing China, 3 – 6 December 2005

Modiba P. VCT: The entry point to HIV care and treatment. 1st Conference on Priorities in AIDS Care and Treatment, Muldersdrift, Johannesburg, 19 – 22 April 2005

Palmer S, Boltz V, Maldarelli F, Martinson N, Gray G, McIntyre J, Mellors J, Morris L, Coffin J. Persistence of NNRTI-r resistant variants after single-dose nevirapine in HIV-1 subtype-C-infected women. Abstract 101. 12th Conference on Retroviruses and Opportunistic Infections. 22-25 February 2005. Boston, MA.

Pato, S., 2005, Challenges in the development and implementation of the informed consent process. Workshop on the Informed Consent in HIV Prevention Trials, 16 – 18 May 2005, New York.

Vardas E, Panteleo G, Bart PA, Robinson A, Thomas R, McIntyre J, Bogoshi M, Mayaphi S, Fast P, Schmit C, Gilmour J, Tarragona T, Smith C, Dally L. Safety and immunogenicity of MVA.HIVA by 3 different routes. (329P). AIDS Vaccine Conference, Montreal, September 6-9, 2005.

Violari A. ARV treatment in pregnancy. 1st Conference on Priorities in AIDS Care and Treatment, Muldersdrift, Johannesburg, 19 – 22 April 2005.


Poster presentations: 2005

Gray GE, McIntyre JA, Martinson N, Hopley M, Hall D, Mayers D for the Treatment Options (TOPS) Trial/1413 Investigator Team. NNRTI-resistant mutations in HIV-infected infants following single dose nevirapine (sd-NVP) are reduced by the addition of short course zidovudine and 3TC. 3rd Conference on HIV Pathogenesis and Treatment. 24-27 July 2005, Rio de Janeiro.

Heyer AS, Rowe K, Makhubela BM, Hargreaves JR, Porter JDH, Haussler HP, Pronyk PM. Preparing for Antiretroviral Therapy: lessons learned through the provision of TB preventative therapy for HIV positive patients in rural South Africa. South African AIDS conference, Durban, August 2003.

Heyer A, Steyn J, Pronyk P, McIntryre J, Gray G, Struthers H and Martinson N, Prevalence and risk factors for pre-malignant cervical lesions in HIV infected women? 3rd Conference on HIV Pathogenesis and Treatment. 24-27 July 2005, Rio de Janeiro.

Martinson N, Heyer A, Steyn J, Struthers H, McIntyre J, Gray G, Pronyk P. Does WHO clinical stage reliably predict who should receive ARV treatment? Abstract WeFO0304 3rd Conference on HIV Pathogenesis and Treatment. 24-27 July 2005, Rio de Janeiro.

Mast TC, Kierstead L, Gupta S, Nikas A, Kallas E, Novitsky V, Mbewe B, Pitisuttithum, Schecter M, Vardas E, Wolfe N, Aste-Amezaga, Shriver J, Coplan P, Straus W. Epidemiology of human pre-existing anti-adenovirus type-6 (AD6) and type-5 (AD5) neutralizing antibodies (NA) in areas representative of potential HIV vaccine trial sites. (304P). AIDS Vaccine Conference, Montreal, September 6-9, 2005.

McIntyre J, Martinson N, Gray GE for the Treatment Options (TOPS) Trial/1413 Investigator Team, Single dose nevirapine combined with a short course of combivir for prevention of mother to child transmission of HIV-1 can significantly decrease the subsequent development of maternal and infant resistant virus. 3rd Conference on HIV Pathogenesis and Treatment. 24-27 July 2005, Rio de Janeiro.

Mesesan K, Mlungwana O, Van Niekerk R, Gray G, McIntyre J, Niccolai L, Vardas E. Self-reported risk behaviours of a cohort undergoing screening and enrolment into multiple phase I/II HIV vaccine trials in Soweto, South Africa. (351P). AIDS Vaccine Conference, Montreal, September 6-9, 2005.

Mohlahlane R, Crewe M, Brouard P, Maritz J, Vardas E, Bogoshi M. “Finding the way”: A process of preparing communities for AIDS vaccine trials in a developing country. (602P). AIDS Vaccine Conference, Montreal, September 6-9, 2005.

Struthers HE, McIntyre JA, James KH and Whiting SA, A model of support for antiretroviral treatment in rural South Africa. 3rd Conference on HIV Pathogenesis and Treatment. 24-27 July 2005, Rio de Janeiro.

Vardas E, Mlungwana O, Van Niekirk R, Mesesan K, Mogale M, Mayaphi S, McIntyre J, Gray G. Characteristics of a cohort of individuals screened for phase I/II HIV vaccine trials in South Africa. (344P). AIDS Vaccine Conference, Montreal, September 6-9, 2005.


Abstracts co-authored by PHRU staff (presented or accepted for presentation): 2005

De Bruyn G, Botha J, Nkala B, McIntyre J, Gray G and the MIRA Team. Baseline risk behaviors for prevalent sexually transmitted infections in a large prevention trial in Soweto, South Africa. Abstract 346P. AIDS Vaccine 05. September 2005, Montreal, Canada.

Nkala B, Pato S, Monthato M, Motha P, Sithole T, McIntyre J, Gray G, de Bruyn G. Challenges in recruiting women to HIV prevention trials: Informal settlement compared with established townships. Abstract accepted to: 12th Priorities in Reproductive Health conference. October 2005, Stellenbosch, South Africa.

Robertson G, McIntyre J, de Bruyn G, Dladla S, Gray G. Couple counselling and HIV testing in Soweto: Initial uptake and response. 2nd South African AIDS Conference, June 2005, Durban, South Africa.

Van der Straten A, Lee M, Montgomery E, Blanchard K, Ramjee G, de Bruyn G, Padian N. Characteristics of non-disclosers of diaphragm use among Southern African women enrolled in a HIV prevention trial. Abstract 506. 16th Biennial Meeting of the International Society for Sexually Transmitted Disease Research. July 2005, Amsterdam, Netherlands.


Media Publications: 2005

Garson P. “Men think we bring the disease”: challenges facing HIV-positive women in Soweto. In Baby Steps: Reporting on the prevention of mother-to-child transmission in South Africa, 2005. (pdf: 518kb)

HIV/AIDS and the Media Project. Baby Steps: Reporting on the prevention of mother-to-child transmission in South Africa. 2005. (available on journAIDS)

HIV/AIDS and the Media Project. Secrets and Lies? The ethics of HIV/AIDS reporting in South Africa. 2005. (available on journAIDS) (pdf: 392kb)

Ridgard N. “If you want to see me bright, touch on the question”: attitudes of health care workers to the PMTCT programme in a rural area. In Baby Steps: Reporting on the prevention of mother-to-child transmission in South Africa, 2005. (pdf: 518kb)

Spurr N. “Who is setting the PMTCT agenda?” A quantitative content analysis of media coverage of PMTCT in South Africa. In Baby Steps: Reporting on the prevention of mother-to-child transmission in South Africa, 2005. (pdf: 518kb)

Media articles: 2005

Davidson R. Reflections on yesterday. HIV/AIDS Indaba, 1 April 2005.

Garson P. The nevirapine controversy and the media. HIV/AIDS Indaba, 1 April 2005.

Garson P. It helps when you know you’re not alone. Sunday Independent, 5 June 2005.

Garson P. HIV-positive men come to terms with their status. Irin Plus News, 7 June 2005.

Garson P. Don’t forget girls like to have sex, sometimes skin to skin. Sunday Independent, 12 June 2005.

Garson P. Men behaving positively. Sunday Times, 12 June 2005.

Garson P. Fear of stigma still prevents disclosure. Irin Plus News, 13 June 2005.

Garson P. Challenging stigma by living positively with HIV. Irin Plus News, 21 June 2005.

Masango P. Ntombenhle’s Story. HIV/AIDS Indaba, 1 April 2005.

Spurr N. Is childbirth an absolute right? Mail and Guardian, 1-7 April 2005.



Posters

  • A model of support for antiretroviral treatment in rural South Africa
    • (pdf: 487kb)
  • Single dose nevirapine combined with a short course of combivir for prevention of mother to child transmission of HIV-1 can significantly decrease the subsequent development of maternal and infant resistant virus (pdf: 408kb)
  • Prevalence and risk factors for pre-malignant cervical lesions in HIV infected women? (pdf: 310kb)
  • NNRTI-resistant mutations in HIV-infected infants following single dose nevirapine (sd-NVP) are reduced by the addition of short course
    zidovudine and 3TC (pdf: 91kb)
  • Does WHO clinical stage reliably predict who should receive ARV treatment decisions? (pdf: 172kb)

Events

See a list of presentations to download
  • Conference: (October 2004)
    Title: Priorities in AIDS care and treatment
For a CD of the conference proceedings and presentations please contact Jenny Bowman on +27 (11) 989-9714 or e-mail This e-mail address is being protected from spambots. You need JavaScript enabled to view it .